Olympic 400m silver medallist Christine Ohuruogu was second in 50.67 seconds at the Aviva Birmingham Grand Prix in a race won by Jamaican Rosemarie Whyte.
"It was great out there today," Ohuruogu said. "It's always great to come back home and run in Britain, I think the Olympics showed that. The British crowd are pretty spectacular and they help to lift any event."
Olympic 100m silver medallist Carmelita Jeter got the better of champion Shelly-Ann Fraser-Pryce, winning the 100m in a meeting record 10.81s.
Olympic champion Aries Merritt claimed another victory in the 110m hurdles, clocking 12.95 seconds into a headwind, as Lawrence Clarke, fourth in the final in London, was sixth in 13.52.
Laura Weightman and Hannah England were second and fourth respectively in the 1500m, while Martyn Rooney and Conrad Williams were a disappointing sixth and eighth in the 400m.