British number one Johanna Konta will face qualifier Kaja Juvan of Slovenia in the first round of the Australian Open.
The 2016 semi-finalist is seeded 13 in Melbourne and could face defending champion Sofia Kenin in the round of 16.
Elsewhere, 20-year-old Francesca Jones is all set for her main-draw Grand Slam bow. Jones qualified in style by winning three qualifying matches in Dubai in January and will take on American Shelby Rogers in the first round.
The world number 245, who hails from Bradford, has a rare genetic condition called ectrodactyly ectodermal dysplasia syndrome; she was born with three fingers and a thumb on each hand, three toes on her right foot and four toes on her left.
But Jones' determination to prove any doubters wrong has been ever-present on her tennis journey to date and she hopes to continue doing so in her maiden Grand Slam.
"A lot of people would say it's a disadvantage, whereas I would beg to differ: I always feel like it's an advantage," she told BBC Sport earlier this year.
"I feel it puts me a step ahead of them in many ways and I've learned to be independent. It's taught me a lot about myself and about life.”
Meanwhile there will be a sense of déjà-vu for Heather Watson when she takes on Czech Kristyna Pliskova, who she overcame in the first round of last year's competition.
Katie Boulter, continuing her comeback after a back injury, will take on Russia's Daria Kasatkina.
In the men's draw, there were just two Brits and they were drawn together as Cameron Norrie takes on 30th seed Dan Evans.
The pair played each other as recently as December 23, when Norrie triumphed 6-3, 6-2 in the LTA's Battle of the Brits series.
This will be the Davis Cup teammates' first head-to-head meeting at ATP level and Evans admitted to a sense of frustration at being drawn to play his compatriot.
"It's unfortunate that two Brits play each other. It's a long way to come to play each other," said the 30th seed.
"But it will be a good match and will be good fun. Hopefully I win. It's a difficult match, though.
"Obviously Cameron would know me better than most. He beat me last time, when we were in lockdown in London, so I'm the underdog. The pressure is on him."
Should the victor of the Evans-Norrie clash go on to win their second-round clash next week, they are likely to meet Rafael Nadal in the third round.
Andy Murray, who was ruled out the tournament after returning a positive Covid-19 test, will return to the court in an ATP Challenger tournament in Italy next week.