European fencing champion Simona Gherman proved too strong for Britain's Corinna Lawrence in the last 32 of the women's epee at the ExCeL.
The 22-year-old from Plymouth had beaten Chilean Caterin Bravo Aranguiz 15-12 in the first round, but lost 15-9 to a quality opponent ranked fourth in the world.
After three days of action the crowd has yet to see a home fencer reach the last 16, but main medal hope Richard Kruse goes in the men's foil on Tuesday along with James Davis and Husayn Rosowsky.
Lawrence, 43rd in the world, was level at 3-3 midway through the opening period of three minutes, but then fell 7-3 down in the space of the next 80 seconds.
She scored the first point of the second period, but after a premature halt to the round because of a lack of action - Lawrence had decided that with her coach to try to keep the contest tighter - Gherman showed her class to advance.
She said: "She is number four in the world and has just won the European title. I did as much as I could and I have no regrets."
The Wembley-based fencer, who also has a green belt in taekwondo, has been combining her training with finance exams at Westminster Business School as well as some teaching.
She hopes to be in a position to go full-time in the run-up to Rio in 2016 and added: "With the sponsorship we've had my fencing has gone up and I feel if I can do it for four years there will be no stopping me."