British quartet Dwain Chambers, Mark Lewis-Francis, Andrew Robertson and Simeon Williamson all failed to advance from the 100m heats in the athletics Aviva London Grand Prix at Crystal Palace.
Chambers was the the quickest in 10.35s, but American Tyson Gay won the final in a time of 10.03s into a headwind of 1.2 metres per second.
Gay's compatriot Ryan Bailey and Jamaican Nesta Carter finished second and third respectively.
"I'm in pretty good shape, I just need to work on some things on my groin area with my physio and I should be good to go," the former world champion said.
"I feel I know how to mentally prepare for this type of weather and this was the best place to prepare for the Games."